Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.Interactive Jak_Stat Signaling Pathway
Mar 09, 2017
Interactive Jak_Stat Signaling Pathway
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway cascades to transduce cellular signals for development and homeostasis. The JAK-STAT signaling pathway is a critical component of cytokine receptor and growth factor systems regulating growth, survival, differentiation, and activation of the immune system. JAK activation plays a role in specific cellular processes such as cell proliferation, cell migration and apoptosis. Mutational downregulation of the JAK/STAT pathway affects hematopoiesis, immune system development, adipogenesis, and other processes. Upregulation caused by specific mutations contributes to inflammatory disease, erythrocytosis, and cancers, among other disorders.
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