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CD8 alpha&beta Heterodimer
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01731(CD8 alpha)&P10300(CD8 beta) |
|---|---|
| Species | Mouse |
| Sequence | Lys28-Tyr196(CD8 alpha) acidic tail and Leu22-Thr175(CD8 beta) basic tail |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 24.80 kDa (CD8 alpha) and 23.17 kDa (CD8 beta) |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, (pH 7.4). |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background | CD8 alpha&beta (CD8αβ) is a heterodimeric form of CD8. CD8α is required for surface expression of CD8β. The extracellular IgV-like domain of CD8α interacts with the α3 portion of the class I MHC molecule. CD8αβ is expressed on human peripheral T cells and functions as a coreceptor and can greatly increase the sensitivity and breadth of antigen recognition by CD8+ peripheral T cells bearing TCR. |
|---|
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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Cat# PVGS1940
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