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Siglec-2/CD22
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P20273-1 |
|---|---|
| Species | Human |
| Sequence | Asp20-Arg687 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized Siglec-2/CD22[Biotin], His & Avi, Human at 1 µg/ml (100 µl/well) on the streptavidin precoated plate (5 µg/ml) can bind Anti-Siglec-2 Antibody, hFc Tag. Test result was comparable to standard batch. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 78.1 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, (pH 7.4). |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background | CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. |
|---|
Research Areas
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Cat# PVGS1939
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