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CD3E/CD3 epsilon
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| Primary Accession | P07766 |
|---|---|
| Species | Human |
| Sequence | Asp23-Asp126 |
| Purity | > 95% as determined by Bis-Tris PAGE |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized CD3E/CD3 epsilon, His, Human at 1 µg/ml (100 µl/well) on the plate can bind Anti-CD3 Antibody, hFc Tag. Test result was comparable to standard batch. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 12.6 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS，(pH 7.4). |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 916 |
|---|---|
| Other Names | T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E |
| Target Background | CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. |
| Name | CD3E |
|---|---|
| Synonyms | T3E |
| Function | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down- regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK- NFkB signaling cascade and calcium influx (PubMed:38614099). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Research Areas
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Cat# PVGS1870
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