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CD3E&CD3D
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07766 (CD3E)&P04234 (CD3D) |
|---|---|
| Species | Human |
| Sequence | Asp23-Asp126 (CD3E)&Phe22-Ala105 (CD3D) |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized CD3E&CD3D [Biotin], His, Human at 0.5 µg/ml (100 µl/well) on the streptavidin precoated plate (5 µg/ml) can bind OKT3, mFc Tag. Test result was comparable to standard batch. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 17.9 kDa (CD3E) and 16.7 kDa (CD3D) |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS，(pH 7.4). |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background | T-cell surface glycoprotein CD3 epsilon&CD3 delta chain, also known as CD3E&CD3D, are single-pass type I membrane proteins. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. |
|---|
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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Cat# PVGS1847
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