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MSLN/Mesothelin
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13421-3 |
|---|---|
| Species | Human |
| Sequence | Glu296-Leu591 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Immobilized MSLN/Mesothelin(296-591), His, Human (Cat.No.: Z03859) at 2 µg/ml (100 µl/Well) on the plate can bind Biotinylated Human CA125, His Tag. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 34.48 kDa |
| Formulation | Lyophilized from a 0.22 µm filtered solution in PBS, pH 7.4. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background | Mesothelin, also known as MSLN, is encoded by the MSLN gene. It encodes a precursor protein of 71 kDa that is processed to a 31 kDa shed protein called megakaryocyte potentiating factor (MPF) and a 40 kDa fragment, mesothelin. MSLN is attached to the cell membrane by a glycosyl-phosphatidylinositol (GPI) anchor. It is a differentiation antigen which is highly expressed in several human cancers, including virtually all mesotheliomas and pancreatic adenocarcinomas. |
|---|
Research Areas
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Cat# PVGS1735
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