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Activin A
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08476 |
|---|---|
| Species | Human |
| Sequence | Gly311-Ser426 |
| Purity | > 95% as determined by Bis-Tris PAGE |
| Endotoxin Level | Less than 0.1EU per µg by the LAL method. |
| Biological Activity | Immobilized Activin A, Human (Cat.No.: Z03814) at 1 µg/ml can bind Human Activin RIIB, His Tag. Activin A, Human (Cat.No.: Z03814) can inhibit proliferation of MPC-11 cells. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 12.97 kDa |
| Formulation | Lyophilized from 0.22 µm filtered solution in 4 mM HCI. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in 4mM HCI. |
| Storage & Stability | Upon receiving, the lyophilized product remains stable up to 6 months at -20 °C or below as supplied from date of receipt.-80°C for 3 months after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Gene ID | 3624 |
|---|---|
| Other Names | Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA |
| Target Background | Activin-A, a member of the TGF-β superfamily, has fundamental roles in embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation, and tissue fibrosis. It signals through two type I and two type II receptors, activating kinase activity, phosphorylating SMAD2 and 3 intracellular signaling mediators, forming a complex with SMAD4, and translocating to the nucleus to regulate gene expression. |
| Name | INHBA |
|---|---|
| Function | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Cellular Location | Secreted. |
Research Areas
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Cat# PVGS1696
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