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FGF-basic
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | XP_035600424.1 |
|---|---|
| Species | Salmon |
| Sequence | Full length |
| Purity | ≥ 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | EC50 < 1.0 ng/ml as determined by a dose-response proliferation assay using murine Balb/c 3T3 cells. Based on the EC50, the calculated specific activity is approximately > 1.0 × 106 IU/mg. It is recommended to experimentally determine the optimal concentration for each specific application by performing a dose response assay. |
| Expression System | E. coli |
| Theoretical Molecular Weight | 17.1 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 7.8 mM Na2HPO4, 1.5 mM KH2PO4, 2.7 mM KCl, 500 mM NaCl. |
| Reconstitution | Before opening, centrifuge the vial briefly to bring the contents to the bottom. Reconstitute the lyophilized powder in PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, the lyophilized product remains stable for up to 6 months at lower than -70 °C. Upon reconstitution, the product is stable for up to 1 week at 4 °C or up to 3 months at -20 °C. Avoid repeated freeze-thaw cycles by making single-use aliquots before the solution is storage at -20 °C. |
| Target Background | Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the β trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomyocytes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury. |
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Research Areas
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Cat# PVGS1686
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