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4-1BBL/TNFSF9
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P41273 |
|---|---|
| Species | Human |
| Sequence | Arg71-Glu254 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | ≤ 1 EU/ µg of protein by LAL method |
| Expression System | E. coli |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 20 mM Tris-HCl, 150 mM NaCl, pH 7.4. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4-7°C and up to 3 months at -20 °C or below. Avoid repeated freeze-thaw cycles. |
| Gene ID | 8744 |
|---|---|
| Other Names | Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL, TNFSF9 |
| Target Background | Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4 1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death (AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction. |
| Name | TNFSF9 |
|---|---|
| Function | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation- induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. |
| Cellular Location | Membrane; Single-pass type II membrane protein. |
| Tissue Location | Expressed in brain, placenta, lung, skeletal muscle and kidney |
Research Areas
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Cat# PVGS1635
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