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FGL1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q08830 |
|---|---|
| Species | Human |
| Sequence | Leu23-Ile312 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 1 EU/ µg of protein by gel clotting method |
| Biological Activity | Immobilized h_LAG3 at 5.0 µg/ml (100 µl/well) can bind FGL1, hFc, Human with a linear range of 0.097–50 µg/ml when detected by Mouse Anti-Human IgG Fc-HRP. |
| Expression System | HEK 293 |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 2267 |
|---|---|
| Other Names | Fibrinogen-like protein 1, HP-041, Hepassocin, HPS, Hepatocyte-derived fibrinogen-related protein 1, HFREP-1, Liver fibrinogen-related protein 1 {ECO:0000303|Ref.3}, LFIRE-1 {ECO:0000303|Ref.3}, FGL1 {ECO:0000303|PubMed:18039467, ECO:0000312|HGNC:HGNC:3695} |
| Target Background | FGL1 (Fibrinogen-like protein 1), also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), HP-041, hepassocin (HPS), and liver fibrinogen-related protein 1 (LFIRE-1), is a liver-specific secreted protein belonging to the fibrinogen superfamily whose members share a fibrinogen domain at their C-termini. FGL1 is an immune suppressive molecule that inhibits the activation of antigen-specific T cells by acting as a major ligand of LAG3, and binds LAG3 independently of MHC class II. |
| Name | FGL1 {ECO:0000303|PubMed:18039467, ECO:0000312|HGNC:HGNC:3695} |
|---|---|
| Function | Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). |
| Cellular Location | Secreted. Note=Secreted in the blood plasma |
| Tissue Location | Under normal conditions, liver-specific. |
Research Areas
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Cat# PVGS1594
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