TGF-β2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P61812 |
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Species | Human |
Sequence | Ala303-Ser414 |
Purity | > 95% as analyzed by SDS-PAGE |
Endotoxin Level | < 1 EU/ µg of protein by LAL method |
Biological Activity | ED50 < 0.2 ng/ml, measured in a cell proliferation assay using mouse HT-2 cells. |
Expression System | Human Cells |
Formulation | Lyophilized from a 0.2 µm filtered solution in 4 mM HCl. |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 µg/ml. |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Gene ID | 7042 |
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Other Names | Transforming growth factor beta-2 proprotein, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Latency-associated peptide, LAP, Transforming growth factor beta-2, TGF-beta-2, TGFB2 |
Target Background | Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). |
Name | TGFB2 |
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Function | [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. |
Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137} |

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