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TGF-β1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04202 |
|---|---|
| Species | Mouse |
| Sequence | Ala279-Ser390 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 1 EU/ µg of protein by LAL method |
| Biological Activity | ED50 is 5-25 pg/ml, measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells. |
| Expression System | Human Cells |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 4 mM HCl. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 21803 |
|---|---|
| Other Names | Transforming growth factor beta-1 proprotein, Latency-associated peptide, TGF-beta-1, Tgfb1 {ECO:0000312|MGI:MGI:98725} |
| Target Background | Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, hematopoietic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
| Name | Tgfb1 {ECO:0000312|MGI:MGI:98725} |
|---|---|
| Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137} |
| Tissue Location | Expressed in cardiomyocytes (PubMed:26858265). Weakly expressed in the mammary glands, with a slight increase of expression following onset of involution (PubMed:19745830) |
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Cat# PVGS1550
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