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TWSG1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Sequence | Cys26-Phe223 (Accession #: Q9GZX9), expressed with N-terminal 8×His |
|---|---|
| Purity | > 95% as analyzed by SDS-PAGE and HPLC. |
| Endotoxin Level | < 0.2 EU/ µg, determined by LAL method. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 µg/ml. |
| Target Background | Twisted gastrulation (TWSG1 or TSG) is a cysteine-rich 24 kDa glycoprotein. It is a secreted BMP binding protein that modulates BMP ligand availability in extracellular space. Human TSG shares 98% aa identity with mouse and rat TSG, and 99.5% aa identity with canine, equine, bovine and porcine TSG. Glycosylation and bioactivity of TWSG1 recombinant proteins vary markedly by cellular source. Non-glycosylated hTWSG1 made in E. coli has both reduced affinity for BMPs, as shown by surface plasmon resonance analysis, and reduced BMP inhibitory activity in a mandibular explant culture system compared to glycosylated proteins made in insect cells or mouse myeloma cells. Recombinant human Twisted Gastrulation (TSG), produced in HEK 293 cells is a polypeptide chain containing 211 amino acids. A fully biologically active molecule, rhTSG has a molecular mass of 30~33 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at . |
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Research Areas
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Cat# PVGS1510
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