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MIP-2/CXCL2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10889 |
|---|---|
| Species | Mouse |
| Sequence | Ala28-Asn100 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | The EC50 value of Mouse MIP-2/CXCL2 on Ca2+ mobilization assay in CHO-K1/mCXCR2 (mouse CXCR2 stably expressed in CHO-K1 cells) is less than 200.0 ng/ml. |
| Expression System | HEK 293 |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 20310 |
|---|---|
| Other Names | C-X-C motif chemokine 2, Macrophage inflammatory protein 2, MIP2, Cxcl2, Mip-2, Mip2, Scyb2 |
| Target Background | Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also referred to as macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2’s amino acid sequence is 90% identical to the amino acid sequence of related chemokine, CXCL1. CXCL2 signals through the CXCR2 receptor. |
| Name | Cxcl2 |
|---|---|
| Synonyms | Mip-2, Mip2, Scyb2 |
| Function | Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. |
| Cellular Location | Secreted. |
Research Areas
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Cat# PVGS1484
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