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MDC/CCL22
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00626-1 |
|---|---|
| Species | Human |
| Sequence | Pro26-Gln93 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | The EC50 value of human MDC/CCL22 (67aa) on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR4cells (human Gα15 and human CCR4 stably expressed in CHO-K1 cells) is less than 1.0 µg/ml. |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Target Background | Macrophage-Derived/CCL22 Chemokine (MDC) , also known as stimulated T cell chemotactic protein (STCP1), is a CC chemokine initially isolated from clones of monocytederived macrophages. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL22 shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. CCL22 has mild chemotactic activity for primary activated T lymphocytes and no chemoattractant activity for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also be involved in certain aspects of activated T lymphocyte physiology, such astrafficking activated T lymphocytes to inflammatory sites. CCL22 interacts with the cell surface chemokine receptor CCR4. |
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Research Areas
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Cat# PVGS1473
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