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FGF-21
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9JJN1 |
|---|---|
| Species | Mouse |
| Sequence | Ala29-Ser210 |
| Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | ED50 < 0.5 µg/ml,measured by a cell proliferation assay using NIH-3T3 cells in the presence of 1.25 µg/ml mouse Klotho and 10.0 µg/ml heparin, corresponding to a specific activity of > 2.0 × 103 units/mg. |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 56636 |
|---|---|
| Other Names | Fibroblast growth factor 21, FGF-21, Fgf21 |
| Target Background | Fibroblast growth factor-21 (FGF21) belongs to the large FGF family which has at least 23 members. Along with FGF-19/15 and FGF-23, FGF-21 is categorized as a member of the atypical FGF subfamily, as it must be complexed to the Klotho co-receptor in order to bind to the FGF receptors and activate the downstream signaling pathway. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. |
| Name | Fgf21 |
|---|---|
| Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. |
| Cellular Location | Secreted. |
| Tissue Location | Most abundantly expressed in the liver, also expressed in the thymus at lower levels (PubMed:10858549, PubMed:30389664). Expressed in skeletal muscle (at protein level) Secreted in plasma (at protein level) (PubMed:30605666) |
Research Areas
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Cat# PVGS1472
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