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FGF-17
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60258 |
|---|---|
| Species | Human |
| Sequence | Thr23-Thr216, expressed with an N-terminal Met |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | ED50 < 0.5 ng/ml, measured by the cell proliferation assay using Balb/c3T3 cells, corresponding to a specific activity of > 2.0 × 106 units/mg. |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 8822 |
|---|---|
| Other Names | Fibroblast growth factor 17, FGF-17, FGF17 |
| Target Background | Fibroblast Growth Factor-17 (FGF-17) is a heparin binding growth factor that is a member of the FGF family. Proteins of this family play multiple roles in biological functions, including angiogenesis, mitogenesis, cell differentiation and wound repair. FGF-17 plays an important role in organizing and inducing specific patterning at the midbrain/hindbrain junction. FGF-17 is also expressed in the hindgut, parts of thedeveloping skeleton, tail bud, major arteries, and heart. FGF-17 signals through hFGFR1c, 2c, 3c, and 4. FGF-17 signals induce patterning of the embryonic brain. |
| Name | FGF17 |
|---|---|
| Function | Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. |
| Cellular Location | Secreted. |
| Tissue Location | Preferentially expressed in the embryonic brain. |
Research Areas
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Cat# PVGS1458
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