CCL23, Human
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | AAC63327 |
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Species | Human |
Sequence | MLWRRKIGPQ MTLSHAAGFH ATSADCCISY TPRSIPCSLL ESYFETNSEC SKPGVIFLTK KGRRFCANPS DKQVQVCVRM LKLDTRIKTR KN |
Purity | > 98% as analyzed by SDS-PAGE. |
Endotoxin Level | < 0.2 EU/ µg, determined by LAL method. |
Formulation | Lyophilized after extensive dialysis against PBS. |
Reconstitution | Reconstituted in ddH2O or PBS at 100 µg/ml. |
Target Background | Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells. CCL23 is a ligand for the chemokine receptor CCR1. Recombinant human Ck beta 8‑1/CCL23 produced in CHO cells is a single polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhCk beta 8‑1/CCL23 has a molecular mass of 10.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at . |
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