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CXCL1, NAP-3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14095 |
|---|---|
| Species | Rat |
| Sequence | APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK |
| Purity | > 95% as analyzed by SDS-PAGE. |
| Endotoxin Level | < 0.2 EU/ µg, determined by LAL method. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 µg/ml. |
| Gene ID | 81503 |
|---|---|
| Other Names | Growth-regulated alpha protein, C-X-C motif chemokine 1, Cytokine-induced neutrophil chemoattractant 1, CINC-1, Platelet-derived growth factor-inducible protein KC, Cxcl1, Cinc1, Gro, Scyb1 |
| Target Background | GRO/MGSA/CXCL1 has chemotactic activity for neutrophils. It may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. |
| Name | Cxcl1 |
|---|---|
| Synonyms | Cinc1, Gro, Scyb1 |
| Function | Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation. |
| Cellular Location | Secreted. |
| Tissue Location | At least expressed in the lung and trachea. |
Research Areas
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Cat# PVGS1296
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