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MCP-1/CCL2, Rat
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14844 |
|---|---|
| Sequence | Gln24-Asn148 |
| Purity | > 95% as analyzed by SDS-PAGE and HPLC. |
| Endotoxin Level | < 0.2 EU/ µg, determined by LAL method. |
| Gene ID | 24770 |
|---|---|
| Other Names | C-C motif chemokine 2, Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Small-inducible cytokine A2, Ccl2, Je, Mcp1, Scya2 |
| Target Background | MCP-1/CCL2, Rat |
| Name | Ccl2 |
|---|---|
| Synonyms | Je, Mcp1, Scya2 |
| Function | Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). |
| Cellular Location | Secreted. |
Research Areas
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Cat# PVGS1271
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