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Endostatin
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P39060 |
|---|---|
| Species | Human |
| Sequence | Ala1571-Lys1754 |
| Purity | > 97% as analyzed by SDS-PAGE |
| Endotoxin Level | < 1 EU/ µg of protein by gel clotting method |
| Biological Activity | Determined by Endothelial Cell Tube Formation. The cells treated with 10 µg/ml Endostatin showed significant anti-angiogenesis effect. |
| Expression System | P. pastoris |
| Theoretical Molecular Weight | 20.2 kDa |
| Formulation | Lyophilized from a sterile filtered solution in 17 mM citric-phosphate buffer, pH 6.2. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 80781 |
|---|---|
| Other Names | Collagen alpha-1(XVIII) chain, Endostatin, Non-collagenous domain 1, NC1, COL18A1 (HGNC:2195) |
| Target Background | Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. In-vitro studies have shown endostatin blocks the proliferation and organization of endothelial cells into new blood vessels. In animal studies endostatin inhibited angiogenesis and growth of both primary tumors and secondary metastasis. |
| Name | COL18A1 (HGNC:2195) |
|---|---|
| Function | Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:P39061} [Endostatin]: Secreted. Secreted, extracellular space, extracellular matrix, basement membrane |
| Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Present in multiple organs with highest levels in liver, lung and kidney. |
Research Areas
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Cat# PVGS1021
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