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Human CellExp™ Integrin alpha V beta 5 Heterodimer, Human recombinant
Integrin alpha V beta 5, ITGAVB5, ITGAV & ITGB5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P06756, P18084 |
|---|---|
| Calculated MW | 113 kDa |
| Other Names | Integrin alpha V beta 5, ITGAVB5, ITGAV & ITGB5 |
|---|---|
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;> 95% |
| Recombinant | Yes |
| Target/Specificity | ITGAV, ITGB5 |
| Application Notes | Reconstitute in sterile deionized water to the desired protein concentration. |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Integrin alpha V beta 5 (ITGAV & ITGB5 or ITGAVB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAVB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAVB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
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