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Natriuretic Peptide Receptor A Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
| Primary Accession | P16066 |
|---|---|
| Clone Names | 3031007 |
| Gene ID | 4881 |
|---|---|
| Other Names | Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, ANP-A, ANPR-A, NPR-A, Guanylate cyclase A, GC-A, NPR1, ANPRA |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8111a was selected from the N-term region of human ANPA . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NPR1 (HGNC:7943) |
|---|---|
| Synonyms | ANPRA |
| Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
Provided below are standard protocols that you may find useful for product applications.
Background
ANPA is a receptor for atrial natriuretic peptide. It exhibits guanylate cyclase activity on binding of ANF. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction. This Type I membrane protein belongs to the adenylyl cyclase class-4/guanylyl cyclase family and contains 1 protein kinase-like domain.
References
Takahashi, Y., et al., Biochem. Biophys. Res. Commun. 246(3):736-739 (1998).Pardhasaradhi, K., et al., Cell. Mol. Neurobiol. 14(1):1-7 (1994).Lowe, D.G., et al., EMBO J. 8(5):1377-1384 (1989).
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