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APOA4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P06727 |
|---|---|
| Other Accession | A8MSL6 |
| Clone Names | 80118122 |
| Gene ID | 337 |
|---|---|
| Other Names | Apolipoprotein A-IV, Apo-AIV, ApoA-IV, Apolipoprotein A4, APOA4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7591a was selected from the N-term region of human APOA4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | APOA4 |
|---|---|
| Function | May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. |
| Cellular Location | Secreted. |
| Tissue Location | Synthesized primarily in the intestine and secreted in plasma |
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Provided below are standard protocols that you may find useful for product applications.
Background
The primary translation product of the APOA4 gene is a 396-residue preprotein which after proteolytic processing is secreted into its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
References
Chien,K.L., Clin. Chim. Acta 388 (1-2), 78-83 (2008)Bai,H., Acta Cardiol 63 (3), 315-322 (2008)
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