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XRCC1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18887 |
|---|---|
| Other Accession | NP_006288.2 |
| Clone Names | 90625265 |
| Gene ID | 7515 |
|---|---|
| Other Names | DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | XRCC1 {ECO:0000303|PubMed:2247054, ECO:0000312|HGNC:HGNC:12828} |
|---|---|
| Function | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP- ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). |
| Cellular Location | Nucleus. Chromosome Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403). Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814) |
| Tissue Location | Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is involved in theefficient repair of DNA single-strand breaks formed by exposure toionizing radiation and alkylating agents. This protein interactswith DNA ligase III, polymerase beta and poly (ADP-ribose)polymerase to participate in the base excision repair pathway. Itmay play a role in DNA processing during meiogenesis andrecombination in germ cells. A rare microsatellite polymorphism inthis gene is associated with cancer in patients of varyingradiosensitivity.
References
Lamerdin, J.E., et al. Genomics 25(2):547-554(1995)Gyapay, G., et al. Nat. Genet. 7 (2 SPEC NO), 246-339 (1994) :Thompson, L.H., et al. Mol. Cell. Biol. 10(12):6160-6171(1990)Thompson, L.H., et al. Genomics 5(4):670-679(1989)
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