COLQ Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y215 |
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Clone Names | 100528199 |
Gene ID | 8292 |
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Other Names | Acetylcholinesterase collagenic tail peptide, AChE Q subunit, Acetylcholinesterase-associated collagen, COLQ |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | COLQ |
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Function | Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. |
Cellular Location | Synapse. |
Tissue Location | Found at the end plate of skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the subunit of a collagen-like moleculeassociated with acetylcholinesterase in skeletal muscle. Eachmolecule is composed of three identical subunits. Each subunitcontains a proline-rich attachment domain (PRAD) that binds anacetylcholinesterase tetramer to anchor the catalytic subunit ofthe enzyme to the basal lamina. Mutations in this gene areassociated with endplate acetylcholinesterase deficiency. Multipletranscript variants encoding different isoforms have been found forthis gene.
References
Mihaylova, V., et al. Brain 131 (PT 3), 747-759 (2008) :Schreiner, F., et al. Neuromuscul. Disord. 17(3):262-265(2007)Ting, A.K., et al. Chem. Biol. Interact. 157-158, 63-70 (2005) :Dvir, H., et al. EMBO J. 23(22):4394-4405(2004)Ishigaki, K., et al. Neuromuscul. Disord. 13(3):236-244(2003)
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