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TBPL1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Clone Names | 100430167 |
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| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
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| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Initiation of transcription by RNA polymerase II requiresthe activities of more than 70 polypeptides. The protein thatcoordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymeraseproperly, serves as the scaffold for assembly of the remainder ofthe transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and agroup of evolutionarily conserved proteins known as TBP-associatedfactors or TAFs. TAFs may participate in basal transcription, serveas coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly andtranscription initiation. This gene encodes a protein that servesthe same function as TBP and substitutes for TBP at some promotersthat are not recognized by TFIID. It is essential forspermiogenesis and believed to be important in expression ofdevelopmentally regulated genes.
References
Suenaga, Y., et al. J. Biol. Chem. 284(51):35433-35440(2009)Kuzmin, A., et al. Biol. Reprod. 81(2):319-326(2009)Satoh, J., et al. Neuropathol. Appl. Neurobiol. 35(1):16-35(2009)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Chong, J.A., et al. Mol. Cell. Biol. 25(7):2632-2643(2005)
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