PMM2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15305 |
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Clone Names | 100623033 |
Gene ID | 5373 |
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Other Names | Phosphomannomutase 2, PMM 2, PMM2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PMM2 |
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Function | Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes theisomerization of mannose 6-phosphate to mannose 1-phosphate, whichis a precursor to GDP-mannose necessary for the synthesis ofdolichol-P-oligosaccharides. Mutations in this gene have been shownto cause defects in glycoprotein biosynthesis, which manifests ascarbohydrate-deficient glycoprotein syndrome type I. [provided byRefSeq].
References
Vega, A.I., et al. Hum. Mutat. 30(5):795-803(2009)Coman, D., et al. Am. J. Med. Genet. A 146(3):389-392(2008)Vermeer, S., et al. J. Neurol. 254(10):1356-1358(2007)Coman, D., et al. J Clin Neurosci 14(7):668-672(2007)Schollen, E., et al. Mol. Genet. Metab. 90(4):408-413(2007)
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