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SHROOM2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13796 |
|---|---|
| Clone Names | 110726216 |
| Gene ID | 357 |
|---|---|
| Other Names | Protein Shroom2, Apical-like protein, Protein APXL, SHROOM2, APXL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SHROOM2 |
|---|---|
| Synonyms | APXL |
| Function | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). |
| Cellular Location | Apical cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton. Note=Associates with cortical F-actin. |
| Tissue Location | Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene shares significantsimilarities with the apical protein from Xenopus laevis which isimplicated in amiloride-sensitive sodium channel activity. Thisgene is a strong candidate gene for ocular albinism type 1syndrome.
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Dietz, M.L., et al. J. Biol. Chem. 281(29):20542-20554(2006)Hagens, O., et al. BMC Cell Biol. 7, 18 (2006) :
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