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PPIL1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y3C6 |
|---|---|
| Clone Names | 110617281 |
| Gene ID | 51645 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase-like 1, PPIase, Rotamase PPIL1, PPIL1, CYPL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPIL1 |
|---|---|
| Synonyms | CYPL1 |
| Function | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:33220177). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). |
| Cellular Location | Nucleus |
| Tissue Location | Ubiquitous, with the most abundant expression in heart and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the cyclophilin family ofpeptidylprolyl isomerases (PPIases). The cyclophilins are a highlyconserved, ubiquitous family, members of which play an importantrole in protein folding, immunosuppression by cyclosporin A, andinfection of HIV-1 virions. Based on similarity to other PPIases,this protein could accelerate the folding of proteins and mightcatalyze the cis-trans isomerization of proline imidic peptidebonds in oligopeptides.
References
Wang, X., et al. J. Biol. Chem. 285(7):4951-4963(2010)Xu, C., et al. J. Biol. Chem. 281(23):15900-15908(2006)Xu, C., et al. J. Biomol. NMR 31(2):179-180(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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