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LIN54 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6MZP7 |
|---|---|
| Clone Names | 100126058 |
| Gene ID | 132660 |
|---|---|
| Other Names | Protein lin-54 homolog, CXC domain-containing protein 1, LIN54, CXCDC1, KIAA2037 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LIN54 |
|---|---|
| Synonyms | CXCDC1, KIAA2037 |
| Function | Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17531812, PubMed:17671431). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17531812, PubMed:17671431). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence- specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
LIN54 is a component of the LIN, or DREAM, complex, anessential regulator of cell cycle genes (Schmit et al., 2009[PubMed 19725879]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Schmit, F., et al. FEBS J. 276(19):5703-5716(2009)
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