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DHRS6 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BUT1 |
|---|---|
| Clone Names | 81006088 |
| Gene ID | 56898 |
|---|---|
| Other Names | 3-hydroxybutyrate dehydrogenase type 2, 111-, Dehydrogenase/reductase SDR family member 6, Oxidoreductase UCPA, R-beta-hydroxybutyrate dehydrogenase, BDH2, DHRS6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BDH2 {ECO:0000303|PubMed:35150746, ECO:0000312|HGNC:HGNC:32389} |
|---|---|
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity) (PubMed:35150746). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L- proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in liver (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :Guo, K., et al. J. Biol. Chem. 281(15):10291-10297(2006)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
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