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VEGFA Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
| Primary Accession | P15692 |
|---|---|
| Clone Names | 100427016 |
| Gene ID | 7422 |
|---|---|
| Other Names | Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGFA, VEGF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | VEGFA |
|---|---|
| Synonyms | VEGF |
| Function | [N-VEGF]: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia- mediated cell death (By similarity). |
| Cellular Location | [N-VEGF]: Cytoplasm. Nucleus. Note=Cytoplasmic in normoxic conditions and localizes to the nucleus under hypoxic conditions [Isoform L-VEGF189]: Endoplasmic reticulum. Golgi apparatus. Secreted, extracellular space, extracellular matrix [Isoform VEGF165]: Secreted |
| Tissue Location | Higher expression in pituitary tumors than the pituitary gland. [Isoform VEGF165]: Widely expressed. [Isoform VEGF206]: Not widely expressed. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the PDGF/VEGF growth factorfamily and encodes a protein that is often found as a disulfidelinked homodimer. This protein is a glycosylated mitogen thatspecifically acts on endothelial cells and has various effects,including mediating increased vascular permeability, inducingangiogenesis, vasculogenesis and endothelial cell growth, promotingcell migration, and inhibiting apoptosis. Elevated levels of thisprotein is linked to POEMS syndrome, also known as Crow-Fukasesyndrome. Mutations in this gene have been associated withproliferative and nonproliferative diabetic retinopathy.Alternatively spliced transcript variants, encoding either freelysecreted or cell-associated isoforms, have been characterized.There is also evidence for the use of non-AUG (CUG) translationinitiation sites upstream of, and in-frame with the first AUG,leading to additional isoforms.
References
Shrivastava-Ranjan, P., et al. J. Virol. 84(21):11227-11234(2010)Kim, Y.H., et al. Gynecol. Oncol. 119(2):232-236(2010)Yang, Y., et al. Exp. Biol. Med. (Maywood) 235(10):1204-1211(2010)Huez, I., et al. Mol. Endocrinol. 15(12):2197-2210(2001)Tee, M.K., et al. Biochem. J. 359 (PT 1), 219-226 (2001) :
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