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TdT Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04053 |
|---|---|
| Clone Names | 80821091 |
| Gene ID | 1791 |
|---|---|
| Other Names | DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase, DNTT, TDT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DNTT |
|---|---|
| Synonyms | TDT {ECO:0000303|PubMed:11473582} |
| Function | Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the DNA polymerase type-X familyand encodes a template-independent DNA polymerase that catalyzesthe addition of deoxynucleotides to the 3'-hydroxyl terminus ofoligonucleotide primers. In vivo, the encoded protein is expressedin a restricted population of normal and malignant pre-B and pre-Tlymphocytes during early differentiation, where it generatesantigen receptor diversity by synthesizing non-germ line elements(N-regions) at the junctions of rearranged Ig heavy chain and Tcell receptor gene segments. Alternatively spliced transcriptvariants encoding different isoforms of this gene have beendescribed.
References
Kubota, T., et al. Genes Cells 12(8):941-959(2007)O'Malley, D.P., et al. Haematologica 91(8):1139-1140(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Thai, T.H., et al. J. Immunol. 173(6):4009-4019(2004)Liu, L., et al. Am. J. Clin. Pathol. 121(6):810-815(2004)
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