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DARS Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14868 |
|---|---|
| Clone Names | 71228107 |
| Gene ID | 1615 |
|---|---|
| Other Names | Aspartate--tRNA ligase, cytoplasmic, Aspartyl-tRNA synthetase, AspRS, Cell proliferation-inducing gene 40 protein, DARS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DARS1 (HGNC:2678) |
|---|---|
| Synonyms | DARS |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aspartyl-tRNA synthetase (DARS) is part of a multienzymecomplex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetasecharges its cognate tRNA with aspartate during proteinbiosynthesis.
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)Ling, C., et al. J. Biol. Chem. 280(41):34755-34763(2005)Bonnefond, L., et al. Biochemistry 44(12):4805-4816(2005)
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