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GNAT2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
| Primary Accession | P19087 |
|---|---|
| Clone Names | 90121138 |
| Gene ID | 2780 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(t) subunit alpha-2, Transducin alpha-2 chain, GNAT2, GNATC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNAT2 |
|---|---|
| Synonyms | GNATC |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP- phosphodiesterase. |
| Cellular Location | Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P50149}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P50149}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark- adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light {ECO:0000250|UniProtKB:P50149} |
| Tissue Location | Retinal rod outer segment. |
Provided below are standard protocols that you may find useful for product applications.
Background
Transducin is a 3-subunit guanine nucleotide-bindingprotein (G protein) which stimulates the coupling of rhodopsin andcGMP-phoshodiesterase during visual impulses. The transducin alphasubunits in rods and cones are encoded by separate genes. This geneencodes the alpha subunit in cones.
References
Shi, J., et al. Mol. Psychiatry (2010) In press :Thiadens, A.A., et al. Ophthalmology 116(10):1984-1989(2009)Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Oldham, W.M., et al. Nat. Struct. Mol. Biol. 13(9):772-777(2006)Rosenberg, T., et al. Invest. Ophthalmol. Vis. Sci. 45(12):4256-4262(2004)
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