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SLC16A12 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6ZSM3 |
|---|---|
| Other Accession | NP_998771.3 |
| Clone Names | 100111122 |
| Gene ID | 387700 |
|---|---|
| Other Names | Monocarboxylate transporter 12, MCT 12, Creatine transporter 2, CRT2, Solute carrier family 16 member 12, SLC16A12, MCT12 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A12 (HGNC:23094) |
|---|---|
| Function | Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BGC3}; Multi-pass membrane protein. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. |
| Tissue Location | Most highly expressed in kidney, followed by retina, lung, heart and testis. Very weakly expressed in brain and liver. Also detected in lens. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transmembrane transporter that likelyplays a role in monocarboxylic acid transport. A mutation in thisgene has been associated with juvenile cataracts with microcorneaand renal glucosuria.
References
Zuercher, J., et al. Invest. Ophthalmol. Vis. Sci. 51(7):3354-3361(2010)Kloeckener-Gruissem, B., et al. Am. J. Hum. Genet. 82(3):772-779(2008)Halestrap, A.P., et al. Pflugers Arch. 447(5):619-628(2004)
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