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MAML2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8IZL2 |
| Other Accession | A5D7F6 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=125 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 84441 |
|---|---|
| Antigen Region | 780-814 aa |
| Other Names | Mastermind-like protein 2, Mam-2, MAML2, KIAA1819 |
| Dilution | WB~~1:2000 IHC~~1:25 |
| Target/Specificity | This MAML2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 780-814 amino acids from the Central region of human MAML2. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAML2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAML2 |
|---|---|
| Synonyms | KIAA1819 |
| Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. |
| Cellular Location | Nucleus speckle. Note=Nuclear, in a punctate manner |
| Tissue Location | Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
References
Tonon G.,et al.Nat. Genet. 33:208-213(2003).
Tonon G.,et al.Nat. Genet. 33:408-408(2003).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Taylor T.D.,et al.Nature 440:497-500(2006).
Enlund F.,et al.Exp. Cell Res. 292:21-28(2004).
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