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KCNMB2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y691 |
| Other Accession | Q9CZM9, Q811Q0 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Dog, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=27;M=27;R=27 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 10242 |
|---|---|
| Antigen Region | 32-66 aa |
| Other Names | Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Hbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2, KCNMB2 |
| Dilution | WB~~1:2000 |
| Target/Specificity | This KCNMB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the N-terminal region of human KCNMB2. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNMB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNMB2 |
|---|---|
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
References
Wallner M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4137-4142(1999).
Brenner R.,et al.J. Biol. Chem. 275:6453-6461(2000).
Xia X.-M.,et al.J. Neurosci. 19:5255-5264(1999).
Meera P.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000).
Xia X.-M.,et al.J. Gen. Physiol. 121:125-148(2003).
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