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SNRPD3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC |
|---|---|
| Primary Accession | P62318 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=14;M=14 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 6634 |
|---|---|
| Antigen Region | 99-126 aa |
| Other Names | Small nuclear ribonucleoprotein Sm D3, Sm-D3, snRNP core protein D3, SNRPD3 |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Target/Specificity | This SNRPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-126 amino acids from the C-terminal region of human SNRPD3. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNRPD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRPD3 |
|---|---|
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). |
| Cellular Location | Cytoplasm, cytosol. Nucleus. Note=SMN- mediated assembly into core snRNPs occurs in the cytosol before SMN- mediated transport to the nucleus to be included in spliceosomes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.
References
Gonsalvez,G.B., et.al., J. Cell Biol. 178 (5), 733-740 (2007)
Ma,Y., et.al., Structure 13 (6), 883-892 (2005)
Mahler,M., et.al., Arthritis Res. Ther. 7 (1), R19-R29 (2005)
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