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VPS37C Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | A5D8V6 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=39 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 55048 |
|---|---|
| Antigen Region | 142-169 aa |
| Other Names | Vacuolar protein sorting-associated protein 37C, hVps37C, ESCRT-I complex subunit VPS37C, VPS37C, PML39 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This VPS37C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the Central region of human VPS37C. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VPS37C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VPS37C |
|---|---|
| Synonyms | PML39 |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. |
| Cellular Location | Late endosome membrane; Peripheral membrane protein. Note=Probably associates with membranes Recruited to the plasma membrane by HIV-1 |
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Provided below are standard protocols that you may find useful for product applications.
Background
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Eastman, S.W., et al. J. Biol. Chem. 280(1):628-636(2005)
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