Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
P2RX5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB |
|---|---|
| Primary Accession | Q93086 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=47,48,44 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 5026 |
|---|---|
| Antigen Region | 325-353 aa |
| Other Names | P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2RX5, P2X5 |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Target/Specificity | This P2RX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-353 amino acids from the C-terminal region of human P2RX5. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2RX5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX5 (HGNC:8536) |
|---|---|
| Function | [Isoform 6]: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:12761352). Unlike, other P2RX receptors, the P2X5 receptor is also permeable to chloride (PubMed:12761352). May play a supporting role in the inflammatory response (By similarity). |
| Cellular Location | [Isoform 6]: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=The absence of the exon 10-encoded amino acids substantially results in subunit aggregation and retention in the cell cytoplasm |
| Tissue Location | Expressed at high levels in brain and immune system |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.
References
Kotnis, S., et al. Mol. Pharmacol. 77(6):953-960(2010)
Overes, I.M., et al. Cancer Immunol. Immunother. 58(3):429-439(2009)
Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Duckwitz, W., et al. J. Biol. Chem. 281(51):39561-39572(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
