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CHN1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P15882 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=53,50;M=53 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 1123 |
|---|---|
| Antigen Region | 1-30 aa |
| Other Names | N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, NC, Rho GTPase-activating protein 2, CHN1, ARHGAP2, CHN |
| Dilution | WB~~1:1000 |
| Target/Specificity | This CHN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHN1. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CHN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHN1 |
|---|---|
| Synonyms | ARHGAP2, CHN |
| Function | GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
| Tissue Location | In neurons in brain regions that are involved in learning and memory processes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.
References
Volk, A.E., et al. Graefes Arch. Clin. Exp. Ophthalmol. 248(9):1351-1357(2010)
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Miyake, N., et al. Am. J. Med. Genet. A 152A (1), 215-217 (2010) :
Murillo-Correa, C.E., et al. J AAPOS 13(3):245-248(2009)
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