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> home > Products > Primary Antibodies > Antibody Collections > Ribonucleoprotein > SNRPC Antibody (C-term)
SNRPC Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, FC, WB |
|---|---|
| Primary Accession | P09234 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=17;M=17;R=17 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 6631 |
|---|---|
| Antigen Region | 148-179 aa |
| Other Names | U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153} |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Target/Specificity | This SNRPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-179 amino acids from the C-terminal region of human SNRPC. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNRPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRPC {ECO:0000255|HAMAP-Rule:MF_03153} |
|---|---|
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774} |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
SNRPC is associated with snRNP U1.
References
Hochleitner,E.O., J. Biol. Chem. 280 (4), 2536-2542 (2005)
Muto,Y., J. Mol. Biol. 341 (1), 185-198 (2004)
Forch,P., EMBO J. 21 (24), 6882-6892 (2002)
Gunnewiek,J.M., Nucleic Acids Res. 23 (23), 4864-4871 (1995)
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$ 370.00
Cat# AW5526-U100
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