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(Mouse) Suz12 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q80U70 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | M=83;H=83 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 52615 |
|---|---|
| Antigen Region | 496-530 aa |
| Other Names | Polycomb protein Suz12, Suppressor of zeste 12 protein homolog, Suz12, D11Ertd530e, Kiaa0160 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This Mouse Suz12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 496-530 amino acids from the Central region of Mouse Suz12. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Suz12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Suz12 |
|---|---|
| Synonyms | D11Ertd530e, Kiaa0160 |
| Function | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. |
| Cellular Location | Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells |
| Tissue Location | Expressed in embryonic stem cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
References
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Pasini D.,et al.EMBO J. 23:4061-4071(2004).
Umlauf D.,et al.Nat. Genet. 36:1296-1300(2004).
Kuzmichev A.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:1859-1864(2005).
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