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Mouse Pax6 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P63015 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | M=47;H=47;R=47 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 18508 |
|---|---|
| Antigen Region | 404-436 aa |
| Other Names | Paired box protein Pax-6, Oculorhombin, Pax6, Pax-6, Sey |
| Dilution | WB~~1:1000 |
| Target/Specificity | This Mouse Pax6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 404-436 amino acids from the C-terminal region of Mouse Pax6. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Pax6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pax6 |
|---|---|
| Synonyms | Pax-6, Sey |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468). |
| Cellular Location | Nucleus. [Isoform 3]: Nucleus. Cytoplasm |
| Tissue Location | Expressed in osteoclasts. [Isoform 3]: Dominant isoform expressed in the eye, including in the retina and cornea (PubMed:21084637). Weakly expressed in the lens epithelium (PubMed:21084637) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
References
Walther C.,et al.Development 113:1435-1449(1991).
Favor J.,et al.Genetics 159:1689-1700(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Walther C.,et al.Genomics 11:424-434(1991).
Ton C.C.T.,et al.Genomics 13:251-256(1992).
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