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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > GLUL Antibody (N-term)
GLUL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P15104 |
| Other Accession | P46410, P15105, Q4R7U3, P16580, P15103 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Monkey, Mouse, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=42;M=42;R=42 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 2752 |
|---|---|
| Antigen Region | 70-96 aa |
| Other Names | Glutamine synthetase, GS, Glutamate decarboxylase, Glutamate--ammonia ligase, GLUL, GLNS |
| Dilution | WB~~1:1000 IHC-P~~1:25 |
| Target/Specificity | This GLUL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-96 amino acids from the N-terminal region of human GLUL. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLUL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341} |
|---|---|
| Function | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (PubMed:36289327). |
| Cellular Location | Cytoplasm, cytosol. Microsome {ECO:0000250|UniProtKB:P09606} Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane; Lipid-anchor. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane |
| Tissue Location | Expressed in endothelial cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
GLUL belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling.
References
Di Tommaso,L., et.al., J. Hepatol. 50 (4), 746-754 (2009)
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$ 370.00
Cat# AW5446-U100
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