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MAOA Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - MAOA Antibody (C-term) AW5425-U100
    All lanes : Anti-MAOA Antibody (C-term) at 1:1000 dilution Lane 1: human placenta lysates Lane 2: HepG2 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 60 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P21397
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW H=60,45;M=60;R=60 KDa
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 4128
Antigen Region 465-499 aa
Other Names Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A, MAOA
Dilution WB~~1:1000
Target/Specificity This MAOA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 465-499 amino acids from the C-terminal region of human MAOA.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAOA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAOA (HGNC:6833)
Function Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
Cellular Location Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21396}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P21396}; Cytoplasmic side {ECO:0000250|UniProtKB:P21396}
Tissue Location Heart, liver, duodenum, blood vessels and kidney.
Citations (0)
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Background

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

References

Hsu Y.-P.P.,et al.J. Neurochem. 51:1321-1324(1988).
Bach A.W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988).
Chen Z.-Y.,et al.Nucleic Acids Res. 19:4537-4541(1991).
Grimsby J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:3637-3641(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 370.00
Cat# AW5425-U100
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