SCP2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P22307 |
Other Accession | O62742, P32020, P07857 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rabbit |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | H=59,15,50,54,56;M=59,15;R=59,15 KDa |
Isotype | Rabbit IgG |
Antigen Source | HUMAN |
Gene ID | 6342 |
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Antigen Region | 481-515 aa |
Other Names | Non-specific lipid-transfer protein, NSL-TP, Propanoyl-CoA C-acyltransferase, SCP-chi, SCPX, Sterol carrier protein 2, SCP-2, Sterol carrier protein X, SCP-X, SCP2 |
Dilution | WB~~1:1000 |
Target/Specificity | This SCP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 481-515 amino acids from the C-terminal region of human SCP2. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SCP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SCP2 (HGNC:10606) |
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Function | [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl- branched fatty acyl-CoAs (By similarity). |
Cellular Location | [Isoform SCP2]: Peroxisome {ECO:0000250|UniProtKB:P32020}. Cytoplasm. Mitochondrion. Endoplasmic reticulum {ECO:0000250|UniProtKB:P32020}. Mitochondrion {ECO:0000250|UniProtKB:P32020} |
Tissue Location | Liver, fibroblasts, and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
References
Ohba T.,et al.Genomics 24:370-374(1994).
He Z.,et al.DNA Cell Biol. 10:559-569(1991).
Yamamoto R.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:463-467(1991).
Yamamoto R.,et al.Hokkaido Igaku Zasshi 67:839-848(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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