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CD19 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - CD19 Antibody (C-term) AW5355-U100
    All lanes : Anti-CD19 Antibody (C-term)(AW5355) at 1/1000 dilution Lane 1: Daudi whole cell lysates Lane 2: Raji whole cell lysates Lane 3: Ramos whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 95 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P15391
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW H=61 KDa
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 930
Antigen Region 517-551 aa
Other Names B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD19, CD19
Dilution WB~~1:1000
Target/Specificity This CD19 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 517-551 amino acids from the C-terminal region of human CD19.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD19
Function Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126).
Cellular Location Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918}
Tissue Location Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:16672701, PubMed:2463100)
Research Areas
Citations (0)
citation

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Background

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

References

Stamenkovic I.,et al.J. Exp. Med. 168:1205-1210(1988).
Tedder T.F.,et al.J. Immunol. 143:712-717(1989).
Kozmik Z.,et al.Mol. Cell. Biol. 12:2662-2672(1992).
Zhou L.J.,et al.Immunogenetics 35:102-111(1992).
Kuroki K.,et al.Genes Immun. 3:S21-S30(2002).

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$ 370.00
Cat# AW5355-U100
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